Razoplus-DSR Capsules
Razoplus-DSR Capsules
Generic Name
Rabeprazole Sodium 20 mg (Enteric Coated) + Domperidone 30 mg (Sustained Release)
Product Description
Razoplus-DSR is a combination anti-ulcer and prokinetic medicine used for the effective management of acid-related gastrointestinal disorders. It combines Rabeprazole, a Proton Pump Inhibitor (PPI), which reduces stomach acid production, with Domperidone SR, which enhances gastric motility and relieves nausea, vomiting, bloating, and gastric discomfort.
This combination provides long-lasting relief from acidity while improving gastric emptying and reducing reflux symptoms.
Composition
- Rabeprazole Sodium IP (Enteric Coated) equivalent to Rabeprazole 20 mg
- Domperidone IP (Sustained Release) 30 mg
Mechanism of Action (MOA)
Rabeprazole
- Irreversibly inhibits the H+/K+ ATPase (Proton Pump) in gastric parietal cells.
- Suppresses both basal and stimulated gastric acid secretion.
- Promotes healing of gastric and duodenal ulcers.
Domperidone
- Peripheral D2 dopamine receptor antagonist.
- Increases lower esophageal sphincter tone.
- Accelerates gastric emptying.
- Improves gastrointestinal motility.
- Controls nausea and vomiting.
Uses / Indications
Razoplus-DSR is indicated for:
- Gastroesophageal Reflux Disease (GERD)
- Hyperacidity
- Acid reflux
- Gastritis
- Gastric ulcer
- Duodenal ulcer
- Functional dyspepsia
- Heartburn
- Nausea associated with gastric disorders
- Bloating
- Indigestion
- Gastric fullness
- Prevention of NSAID-induced gastric ulcers (when prescribed)
Benefits
- Rapid relief from acidity
- Reduces heartburn
- Prevents acid reflux
- Improves digestion
- Relieves bloating
- Controls nausea and vomiting
- Enhances gastric emptying
- Promotes ulcer healing
- Once-daily convenient dosing
Dosage
- One capsule once daily
- Preferably 30 minutes before breakfast
- Or as directed by the physician.
Swallow the capsule whole. Do not crush or chew.
Common Side Effects
Usually mild and temporary:
- Headache
- Dry mouth
- Constipation
- Diarrhea
- Dizziness
- Abdominal pain
- Flatulence
- Nausea
- Fatigue
Rare but serious:
- Allergic reactions
- Irregular heartbeat (QT prolongation with domperidone)
- Severe diarrhea
- Liver dysfunction (rare)
Precautions
Use with caution in patients with:
- Liver impairment
- Kidney disease
- Cardiac disorders
- Electrolyte imbalance
- Osteoporosis (long-term PPI use)
- Vitamin B12 deficiency (long-term therapy)
- Low magnesium levels
- Pregnancy and breastfeeding (only if prescribed)
Avoid alcohol and smoking, as they may worsen acidity.
Contraindications
Do not use in patients with:
- Allergy to Rabeprazole or Domperidone
- Gastrointestinal bleeding
- Mechanical intestinal obstruction
- Perforation of the stomach or intestine
- Severe liver disease
- Known prolonged QT interval
- Concurrent use of medicines that significantly prolong QT interval unless advised by a physician
Drug Interactions
Use cautiously with:
- Ketoconazole
- Itraconazole
- Digoxin
- Warfarin
- Atazanavir
- Methotrexate (high dose)
- Clarithromycin
- Erythromycin
- Fluoroquinolone antibiotics
- Amiodarone
- Other QT-prolonging medicines
Storage
- Store below 25°C.
- Protect from moisture and direct sunlight.
- Keep out of reach of children.
